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A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus.  Can be seen in ETOH, pyrazinamide, lead and benzene.

A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus. Can be seen in ETOH, pyrazinamide, lead and benzene.

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM.  All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Fatty Acid Oxidation Beta Oxidation in mitocondria @ ~22:14mins Acyl- vs Acetyl CoA I put this in here b/c B12 is important for production of Succinyl Co A (Sideroblastic Anemia) AND Fatty Acid break is loosely related to this by methymaonly Co A,

Fatty Acid Oxidation Beta Oxidation in mitocondria @ ~22:14mins Acyl- vs Acetyl CoA I put this in here b/c B12 is important for production of Succinyl Co A (Sideroblastic Anemia) AND Fatty Acid break is loosely related to this by methymaonly Co A,

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

Anemia can be an underlying symptom of an illness or a sign of a health problem. However, anemia is not a disease itself. If you are unsure if you have anemia, the best way to find out is to go to your doctor and get yourself checked out. There are types of anemia that are caused by the malfunctioning of the body, such as sideroblastic anemia, hemolytic anemia and sickle anemia. These types of anemia cannot be treated with these natural remedies. It requires proper diagnosis and…

Anemia can be an underlying symptom of an illness or a sign of a health problem. However, anemia is not a disease itself. If you are unsure if you have anemia, the best way to find out is to go to your doctor and get yourself checked out. There are types of anemia that are caused by the malfunctioning of the body, such as sideroblastic anemia, hemolytic anemia and sickle anemia. These types of anemia cannot be treated with these natural remedies. It requires proper diagnosis and…

Sideroblastic anemia

Sideroblastic anemia

Iron Metobolism : When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred in. Iron is transported in the blood bound to transferrin and is stored in the liver bound to ferritin. This is why ferritin is measured when assessing iron stores.  Though most of the time you can make the diagnosis of iron deficiency anemia by assessing the patient’s history…

Iron Metobolism : When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred in. Iron is transported in the blood bound to transferrin and is stored in the liver bound to ferritin. This is why ferritin is measured when assessing iron stores. Though most of the time you can make the diagnosis of iron deficiency anemia by assessing the patient’s history…

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Ring Sideroblasts in Sideroblastic Anemia. BM.

Ring Sideroblasts in Sideroblastic Anemia. BM.

21 DIY Home Remedies for Anemia - http://www.myeffecto.com/r/1yid_pn

21 DIY Home Remedies for Anemia - http://www.myeffecto.com/r/1yid_pn

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.