Transmembrane proteins are a kind of integral membrane protein. They go across the whole plasma membrane and very often function to facillitate the transportation of various substances through the plasma membrane.
Protein of the Week: sushi Fun Fact: The intestines, ovaries and liver of fugu (or blowfish) contain a poison called tetrodotoxin, which is 1,200 times deadlier than cyanide (Time Magazine 2010). Science Fact: Sushi domain containing 2 (SUSD2) is a type I transmembrane protein that is highly expressed on breast cancer cells. #antibodies
Cell membranes isolate the cellular environment from its surroundings, providing protection from outside influences. These membranes are covered by transmembrane proteins, which act as "gateways" for communication between the inside and outside of the cell. CXCR4 is a transmembrane protein that plays a significant role in the immune system, and is important for the recruitment of white blood cells. Unfortunately, the HIV virus utilizes CXCR4 as an entry point into host cells, propagating…
Evolution Helps Deduce the Shape of 18 Families of Transmembrane Proteins: Scientists at Harvard Medical School developed algorithms that allowed them to use evolution as their guide to deduce the three-dimensional structure of 18 families of transmembrane proteins.
There are many different kinds of transmembrane proteins found in the plasma membrane. These proteins can be receptors, second-messenger systems, enzymes, channel proteins, carriers, cell-identity markers, or cell-adhesion molecules.